Speeding up the drug-discovery process: advanced techniques, case studies and development of an innovative project

Teachers: 
Credits: 
4
Year of erogation: 
2021/2022
Unit Coordinator: 
Disciplinary Sector: 
Pharmaceutical Chemistry
Semester: 
First semester
Year of study: 
4
Language of instruction: 

Italian

Learning outcomes of the course unit

The course aims to provide students with advanced notions of Pharmaceutical Chemistry complementary to curricular ones, illustrating with practical examples what are the latest generation techniques and approaches to accelerate the development of a new drug.
In order to allow the student to understand how to approach the design of an innovative drug, knowledge on the use of the main pharmaceutical databases will also be provided. These notions will then be used, in the final part of the course, for exercises in the computer room where each student will be guided in the development of a pharmaceutical research project based on original themes provided by the teacher.

Prerequisites

None

Course contents summary

This course will illustrate the main advanced techniques and approaches recently adopted to accelerate the development process of a new drug: polypharmacology, multi-target drugs, drug-repurposing, parallel and combinatorial synthesis, green chemistry, microwave assisted synthesis, flow- chemistry, elctrochemistry and chamical automation. Case studies with practical examples of application in the development of drug candidates will be presented for each of the techniques described. The course will end with exercises in the computer room for research on databases aimed at developing, for each student, an innovative pharmaceutical research project.

Course contents

This course will illustrate the main advanced techniques and approaches recently adopted to accelerate the development process of a new drug: polypharmacology, multi-target drugs, drug-repurposing, parallel and combinatorial synthesis, green chemistry, microwave assisted synthesis, flow- chemistry, elctrochemistry and chamical automation. Case studies with practical examples of application in the development of drug candidates will be presented for each of the techniques described. The course will end with exercises in the computer room for research on databases aimed at developing, for each student, an innovative pharmaceutical research project.

Recommended readings

Handouts and articles provided by the teacher

Teaching methods

The course will be divided into theoretical lessons and exercises in the computer room (or videoconference).

Assessment methods and criteria

Report at the end of the course.

Other informations

Maximum number of participants = 10