TOXICOLOGY

Credits: 
9
Site: 
PARMA
Year of erogation: 
2023/2024
Unit Coordinator: 
Disciplinary Sector: 
Pharmacology
Semester: 
First semester
Language of instruction: 

Italian

Learning outcomes of the course unit

Provide knowledge about the nature of toxic effects of xenobiotics. Provide the general principles of risk assessment

Prerequisites

pharmacology class

Course contents summary

toxic action of xenobiotics and the main regulatory aspects; epidemiology

Course contents

General Section

· General principles of toxicology.

· Mechanisms of toxicity. Toxicity test.

· Absorption, distribution and excretion of toxic substances.

· Biotransformation of xenobiotics.

· Carcinogenesis, teratogenesis, mutagenesis.

 

special section

· Experimental toxicology, epidemiology and toxicological risk assessment.

· Idiosyncratic reactions and allergic diseases, interactions between xenobiotics.

· Toxicology of pesticides, metals, solvents, PAHs, PCB.

· Environmental Toxicology, gas

· food and nutrition Toxicology, Food Additives and Contaminants. Regulatory agencies.

· Occupational Toxicology

· Toxicology of biotechnology products.
 

Recommended readings

teacher's slides

-ERNEST HODGSON: “Tossicologia Moderna”, EdiSES

-CASARETT & DOULL’S: "Tossicologia: fondamenti dell’azione delle sostanze tossiche", Ed. EMSI,

Roma.

-W.A. HAYES: "Principles and Methods of Toxicology", III Edition, Raven Press.

Tossicologia generale e applicata ai farmaci. Balduini-Costa. Ed EDRA

Teaching methods

classroom

Assessment methods and criteria

oral examination