BIOCHEMISTRY

Credits: 
8
Site: 
PARMA
Year of erogation: 
2021/2022
Unit Coordinator: 
Disciplinary Sector: 
Biochemistry
Semester: 
First semester
Language of instruction: 

Italian

Learning outcomes of the course unit

The course provides to students the knowledge on the principles, molecules, macromolecules, interactions, metabolism and regulation of the cell with the aim of understanding the logics of life and the possible strategis for the identification of targets and the development of drugs.

Prerequisites

Knowledge of general and organic chemistry are required

Course contents summary

Principles og living organisms.
Molecular and macromolecular components of cells.
Bond and intra and inter molecular interactions.
Structure, dynamics and function relationships of proteins.
Antibodies.
Myoglobin and hemoglobin.
Allostery and allostreic models.
Enzymes and coenzymes.
Mechanisms of catalysis,inhibition and regulation.
Lipids and biological membranes.
Carbohydrates.
Principles of Principi of metabolsim,and bioenergetics.
Glicolysis, pentose phosphate pathways, gluconeogenesis,Hormone regulation of della degradation and synthesis of glycogen.
Degradation of and synthesis of fatty acids.
Ketone bodies.
Sinthesis and degradation of the heme.
Krebs cycle.
Oxidative phosphorylation,ATP synthesis and photosynthesis.
Degradation and synthesis of amino acids, urea cycle.
Degradation and synthesis of purine and pyrimidine bases.
Organ metabolism.

Course contents

Principles of living organisms.
Molecular and macromolecular components of cells.
Structure, dynamics and function of proteins.
Antibodies.
Myoglobin and hemoglobin.
Allostery and allosteric models.
Enzymes and coenzymes.
Mechanisms of catalysis, inhibition and regulation of enzyme activity.
Lipids and biological membranes.
Carbohydrates.
Principles of metabolism and bioenergetics.
Glycolysis and pentose phosphate pathway. Gluconeogenesis. Degradation and synthesis of glycogen. Hormonal regulation.
Degradation and synthesis of fatty acids.
Ketone bodies.
Krebs cycle.
Oxidative phosphorylation and synthesis of ATP.
Degradation and synthesis of amino acids, urea cycle.
Degradation and synthesis of purines and pyrimidines.

Recommended readings

BERG, TYMOCZKO, STRYER “Biochemistry”, Ed. Zanichelli, Bologna
MATHEWS, VAN HOLDE, AHREN “Biochemistry”, Casa Editrice Ambrosiana, Milano
DEVLIN “Biochemistry”, Ed. EdiSES, Napoli
APPLING, ANTHONY-CAHILL, MATHEWS “Biochemistry”, Pearson
VOET, VOET, PRATT “Principles of Biochemistry”, Ed. Zanichelli, Bologna
GARRET, GRISHAM “Principles of Biochemistry”, Ed. Piccin, Padova
COX “The principles of Biochemistry of Lehninger”, Ed. Zanichelli, Bologna
Campell e Farrell “Biochemistry”, Ed. EdiSES, Napoli

Teaching methods

The course is carried out with a series of lectures with visual means and the involvement of students in order to assess the knowledge and the understanding of different topics.

Assessment methods and criteria

The exam will be usually oral and is aimed at the assessment of the knowledge of biochemistry and the undrstanding of the principles of living systems.